아스파라긴 Asparagine

단백질 ≫ 아미노산 ≫ 아미노산 합성

아스파라긴 Asparagine

- Gluamic acid, glutamine
- Aspartic acid, asparagine
- serine, threonine, glycine, valine
- alanine, leucine, isoleucine
- lysine, arginine, histidine, proline
- methionine, Cysteine
- Tyrosine, Phenylalanie, Tryptophan

콩나물에서 분리 조제 또는 L-아스파르트산-β-에틸에스테르에 암모니아를 작용   시켜 합성
글루타민과 함께 식물 ·미생물 ·동물세포 속에 널리 존재하며 유리 상태로 고등식   물에 축적되며, 동물세포 속에도 존재
생체 내에서는 L-아스파르트산에서 아스파르트나아제의 작용에 의해서 합성
대사경로는 아스파르트산으로 돌아가든지, 아미노기 떨어져나가 옥살아세트산이   되어 TCA회로로 들어감

The nervous system requires asparagine. It also plays an important role in the synthesis of ammonia.

Since the asparagine side-chain can form hydrogen bond interactions with the peptide backbone, asparagine residues are often found near the beginning and the end of alpha-helices, and in turn motifs in beta sheets. Its role can be thought as "capping" the hydrogen bond interactions that would otherwise be satisfied by the polypeptide backbone. Glutamines, with an extra methylene group, have more conformational entropy and thus are less useful in this regard.

Asparagine also provides key sites for N-linked glycosylation, modification of the protein chain with the addition of carbohydrate chains.