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2Â÷Àü·É
Cyclic AMP(cAMP) path
½Å°æÀü´Þ¹°Áú :
2Â÷ Àü·É
-
NO,
CO
-
cAMP,
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G´Ü¹é System :
GPCR
-
cAMP path,
IP path,
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cAMP
- from adenosine triphosphate (ATP)
The cAMP Dependent Pathway is used as a signal transduction pathway for many hormones including:
ADH - Promotes water retention by the kidneys (V2 Cells of Posterior Pituitary)
GHRH - Stimulates the synthesis and release of GH (Somatotroph Cells of Anterior Pituitary)
GHIH - Inhibits the synthesis and release of GH (Somatotroph Cells of Anterior Pituitary)
CRH - Stimulates the synthesis and release of ACTH (Anterior Pituitary)
ACTH - Stimulates the synthesis and release of Cortisol (zona fasiculata of adrenal cortex in kidneys)
TSH - Stimulates the synthesis and release of a majority of T4 (Thyroid Gland)
LH - Stimulates follicular maturation and ovulation in women; Stimulates testosterone production and spermatogenesis in men
FSH - Stimulates follicular development in women; Stimulates spermatogenesis in men
PTH - Increases blood calcium levels (PTH1 Receptor: Kidneys and Bone; PTH2 Receptor: Central Nervous system, Bones, Kidneys, Brain)
Calcitonin - Decreases blood calcium levels (Calcitonin Receptor: Intestines, Bones, Kidneys, Brain)
Glucagon - Stimulates glycogen breakdown (liver)
hCG - Promotes cellular differentiation; Potentially involved in apoptosis
G¥ái inhibits the production of cAMP from ATP.
G¥áq/11 stimulates membrane-bound phospholipase C beta, which then cleaves PIP2 (a minor membrane phosphoinositol) into two second messengers, IP3 and diacylglycerol (DAG).