진화 ≫ 돌연변이 ≫ 항암제
Alkylating agent : Purine, Pyrimidine 염기의 질소를 alkylation 위키
- 예측 가능 or 불가능 ≫ 이미 비슷한 경험
- GMP, 방사선 조사식품
- 항암제
The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage — such as being alkylated. Alkylating agents are used to treat several cancers. However, they are also toxic to normal cells (cytotoxic), leading to damage, in particular in cells that divide frequently, as those in the gastrointestinal tract, bone marrow, and ovaries, which can cause loss of fertility. Alkylating agents are also carcinogenic. Hyperthermia is especially effective at enhancing the effects of alkylating agents.[2]